Estrogen therapy has long been associated with the reduction of hot flashes. What about progesterone? One study found that hormone replacement therapy using oral progesterone may help alleviate menopause-related symptoms, including hot flashes and night sweats.
Drs. Christine L. Hitchcock and Jerilynn C. Prior conducted a study that indicates support for the idea that progesterone helps with post-menopausal symptoms such as hot flashes and night sweats. The 2011 study included 133 healthy women, ages 44 to 62, who received either 300 mg oral progesterone or a placebo for a twelve-week trial period.
The women who took progesterone described significant decreases in the frequency and severity of both day and night-time vasomotor symptoms. In addition, they reported significant improvement in their sleep quality.