Book Review – The LDN Book edited by Linda Elsegood

Book Review – The LDN Book, edited by Linda Elsegood

Written by Carol Petersen, RPh, CNP – Women’s International Pharmacy

Linda Elsegood’s personal success story tells how using low-dose naltrexone (LDN) to treat her multiple sclerosis restored her quality of life and gave her hope for the future. Now she is a woman on a mission to help others learn about LDN and to promote further research into how it may be used to treat a variety of diseases. In The LDN Book: How a Little-Known Generic Drug—Low Dose Naltrexone—Could Revolutionize Treatment for Autoimmune Diseases, Cancer, Autism, Depression, and More, Elsegood has compiled chapters written by practitioners who have become experts in the use of LDN.

History

Pharmacist Stephen Dickson provides a comprehensive history of the opium poppy and the subsequent creation of synthetic drug compounds called opiates, which are all active at the opioid receptor sites. Opioid receptors are meant to be activated by hormones produced in the body called endorphins and enkephalins, which can relieve pain and contribute to wellbeing. However, these receptors can also be stimulated by opiates. Naltrexone was originally developed to block these receptor sites in order to assist people addicted to opiates. The developers of naltrexone reasoned that when opioid receptors were blocked, there would be no need to use or abuse opiate drugs. While a logical theory, in actual practice they had little success.

However, in low doses, naltrexone acts to temporarily block opioid receptors. The body responds by producing increased amounts of endorphins and enkephalins. The opioid receptors also increase in sensitivity and number.

Multiple Sclerosis and Lupus

Dr. Deanna Windham begins with a thorough explanation of multiple sclerosis and lupus. While she recognizes that we do not currently have drugs that treat the complexity of these diseases, LDN has been shown in a number of studies to stabilize and stop their progression. The use of LDN is a pillar in Dr. Windham’s treatment plans, though she maintains that each patient must be treated individually for their toxic load, hormone imbalances, nutrient deficiencies, and sleep issues.

Inflammatory Bowel Diseases

Dr. Jill Smith was the first to publish a study on LDN and inflammatory bowel diseases. There are opioid receptors in the gut and on immune system cells. There are a number of different types of opioid receptors and naltrexone may target different opioid receptors depending on the dose.

Dr. Smith provides case studies of remissions of inflammatory bowel diseases, Crohn’s disease and ulcerative colitis with the use of LDN, both alone and with other commonly-used drugs. LDN blocks opioid receptors for about six hours, during which the body increases its endorphin and encephalin production. After about six hours, the LDN is removed from the opioid receptors by the body and the elevated endorphins and enkephalins can act at the receptor to block cell proliferation or reverse inflammation. LDN also sensitizes and increases the number of receptors. Remission may be confirmed with radiology showing healing of the intestinal tract.

Few of Dr. Smith’s patients have experienced side effects, however, one possible side effect is sleep disturbances, which can be alleviated by changing to a morning dose or using a lower strength.

Thyroid

Dr. Kent Holtorf, president of the National Academy of Hypothyroidism, explores LDN treatment with thyroid disorders. He explains how LDN can be used effectively in both Grave’s Disease (hyperthyroidism) and Hashimoto’s Disease (hypothyroidism). He believes LDN can potentially improve abnormal inflammation and immune dysfunction seen with thyroid disorders, and thus, improve the reduced tissue T3 (active thyroid hormone) levels inside the cells that these conditions can cause. Normal thyroid tests cannot predict the activity of thyroid inside the cell, and so this can go unidentified and untreated.

Chronic Fatigue and Fibromyalgia

Dr. Holtorf also addresses chronic fatigue and fibromyalgia.  He writes about phases of treatment with LDN:

  1. Stabilize the patient. This stage is where pain and sleep disturbances are addressed.
  2. Enhance mitochondrial energy production with nutrients.
  3. Balance hormones as these patients typically have deficiencies.
  4. Enhance the immune system function and treat the infectious components. LDN is often part of this stage of treatment.
  5. Address issues like heavy metals, leaky gut, mold toxicity, and coagulation problems.
  6. Maintain health and balance.

An integrative approach has shown success, with treatment plans adjusted to the individual needs of each patient.

Restless Leg Syndrome

Dr. Leonard Weinstock is a gastroenterologist and internist, with a special interest in restless legs syndrome (RLS) and has identified an association between RLS and small intestine bacterial overgrowth (SIBO) and other inflammatory conditions in the gut. He used LDN to treat patients with and without antibiotics for infection. In each case he found some positive results, and has used LDN for long-term remission.

Depression

Endorphins are very psychoactive, and account for the warm feelings of falling in love, coping with stress, and bringing joy and contentment. Dr. Mark Shukhman describes the symptoms of endorphin deficiency as including:

  • Discomfort with disturbances such as changes in sound, light, temperature, or touch
  • Immune system problems such as frequent infections, allergies, and autoimmune disease
  • Crying easily, and have difficulty with painful situations
  • Craving chocolate, wine, marijuana, and alcohol

LDN helps in these conditions by increasing the levels of endorphins. Many people who have turned to opiates describe that it is the first time that they have felt normal. Although his chapter focuses on depression, psychiatrist Dr. Shukhman has also used LDN in his practice for treatment of autism, post-traumatic stress disorder, multiple personality disorder, anxiety, obsessive compulsive disorder, psychosis, and even sexual dysfunctions.

Autism

Dr. Brian Udell has a special needs pediatric practice and has found a common theme with autism to be inflammation and gut disturbances. He cites Dr. Jacquelyn McCandless’ work with children using LDN as a cream, rather than tablets, because of its bitter taste. He has seen LDN increase speech and communication, decrease aggression, and improve social development. Beta endorphin levels can be measured to confirm LDN activity.

Cancer

Dr. Angus Dalgleish, an oncology practitioner in the UK, writes that, while there is very little in the published literature, LDN seems to be universally useful across all tumor types. He writes of his personal experience treating patients with metastases, achieving stability and long–term, disease-free status. He finds that LDN affects more receptor sites than just the opioid receptors. Naltrexone in large doses actually promotes tumor growth in the laboratory, so the best effects occur when it is used in low doses and used intermittently rather than continuously. Its anti-inflammatory action can be helpful in cancer. Dr. Dalgleish reports that the use of LDN also increases the production of natural killer cells. Finally, LDN can produce positive effects on mood that help in combatting the disease. He writes that failure with LDN may be linked to low vitamin D levels.

Conclusion

The LDN Book is just a part of Linda Elsegood’s work. Under her direction, the LDN Research Trust has an incredible number of accomplishments, including organized conferences, LDN radio, and crowdfunded documentaries. This outreach has stimulated investigation into endocrine and immune system activity that was hardly known before. This book is a window into the large body of knowledge we have gained in the last ten years.

Book Review – The LDN Book edited by Linda Elsegood 2018-02-26T12:09:00+00:00

Book Review – The 6-Week Cure for the Middle-Aged Middle by Mary Dan Eades, MD, & Michael R. Eades, MD

Book Review – The 6-Week Cure for the Middle-Aged Middle by Mary Dan Eades, MD, & Michael R. Eades, MD

Written by Carol Petersen, RPh, CNP – Women’s International Pharmacy

 

scale and measuring tapeHow many middle-aged adults experience weight gain in their midsection?  Even with no changes in diet or exercise, weight gain is commonplace, particularly around the middle. Worse, this area of weight gain is the very abdominal obesity associated with heart disease. Drs. Michael and Mary Dan Eades address ways to eliminate unhealthy fat that accumulates around the organs in their book, The 6-Week Cure for the Middle-Aged Middle.

Drs. Michael Eades and Mary Dan Eades gained fame in the 70s for their weight loss success and their bestselling book, Protein Power. Both physicians lost a considerable amount of weight by incorporating principles they learned as they researched their weight problem. In turn, they successfully helped many others lose weight.

After decades of success, however, a problem arose. As the Eadeses prepared for a televised show, although they continued to follow their own prescription for success, the cameras zeroed in on a problem: a middle-aged spread around the middle. They wondered how they could promote the success of their program with this weight concern.

The Eadeses went back to what had worked for them the first time: research. They set out to find what had sabotaged their program for successful weight loss.

The answer? Hormones.

 

Cortisol and Estrogen

During middle age, the adrenal glands may increase their production of cortisol. This may be provoked by a number of factors including stress or sleep disturbances. The increased cortisol levels send signals to store fat, particularly in the abdominal area.

Weight can be affected by both high and low estrogen levels. With aging, estrogen (the hormone associated with curviness in women) decreases, and may contribute to midlife weight gain. The Eadeses recommend using only bioidentical estrogens, estradiol or estradiol with some estriol, as non-bioidentical therapies may not help with weight and may even worsen it.

The Liver and Hormone Deficiencies

6 week cure for the middle aged middle bookIn middle age, the pancreatic hormone insulin rises, signaling the liver to store more fat. Additionally, as we age, the liver creates more sex hormone binding globulin (SHBG), a protein carrier for hormones. When the hormones are bound to this protein, they are not available for use by the body.  While SHBG levels increase with age, the sex hormones carried by SHBG such as testosterone, DHEA, and estrogens decline with age. Hormone deficiencies can occur as lower levels of hormones are produced overall and more SHBG binds the hormones that are produced, making them unavailable for use by the body. These hormone deficiencies can lead to loss of muscle and bone mass and an increase in body fat percentage.

According to the Eadeses, what happens in middle age is a combination of a number of factors: loss of sleep, increased stress, a diet lacking in fat (due to concerns with cholesterol levels), hormones imbalances, introduction of new medications, and difficulties with nutritional intake. Their book is not a weight loss plan, but a path to “body-rehabilitation,” as fat stores leave the middle and the body becomes leaner and stronger.

A dietary plan to address abdominal weight gain is spelled out in The 6-Week Cure for the Middle-Aged Middle. The Eadeses report great success for themselves and their patients. For those that are struggling with middle aged weight gain, this book may hold the resources needed to help combat it.

Book Review – The 6-Week Cure for the Middle-Aged Middle by Mary Dan Eades, MD, & Michael R. Eades, MD 2018-01-22T10:50:12+00:00

Book Review – Bursting With Energy by Frank Shallenberger

Book Review – Bursting with Energy by Frank Shallenberger, MD, HMD

Written by Carol Petersen, RPh, CNP – Women’s International Pharmacy

 

Bursting with Energy Book CoverDo you have an energy crisis? Dr. Frank Shallenberger poses this question on the back of his book, Bursting with Energy.[i] How many people tell their practitioners that they feel fatigued or lack energy? How many illnesses, such as multiple sclerosis, involve debilitating fatigue? How many teenagers are unable to keep up with their peers because of fatigue? How many individuals notice a lack of energy as they age? Studies show that 15% percent of women and 10% of men often feel very tired or exhausted.[ii]

Dr. Shallenberger argues that diminished energy production is the primary cause of many diseases, including allergies, obesity, diabetes, heart disease, infections, and even aging. “Chronic fatigue syndrome (CFS)” and other fatigue-related illnesses exist, yet are difficult to diagnose and understand.[iii]

Energy production occurs in specialized structures called mitochondria in all cells in the body. It is inside the mitochondria that the molecule, adenosine triphosphate (ATP), is produced to store the energy created. Energy levels are affected by how well the mitochondria function, as well as how many and how efficiently ATP molecules are produced.

The sun is required to begin producing energy in the body. The plant world picks up the sun’s energy and uses it to convert carbon dioxide into oxygen. Once oxygen is inhaled, the lungs help deliver it to the blood stream. The heart and circulatory system distribute the oxygen to the cells, where the mitochondria busily produce energy and the ATP needed to store the energy for the body. Energy production also depends upon our nutrient intake of carbohydrates, fats, and proteins.

What exactly is interfering with this cycle of energy production? Conventional practitioners may have a difficult time evaluating a patient’s symptoms when they complain of fatigue and low energy. They will likely test to determine the level of fatigue, the causes, and what may help alleviate the lack of energy.

Dr. Shallenberger has pioneered a testing procedure called “Bio-Energy Testing,” which can measure how much oxygen the body uses and how much carbon dioxide the body produces. From these values, mitochondrial function is determined. His book thoroughly outlines how this new method allows for the assessment of energy production and identification of issues that can affect fatigue. The success (or lack of success) with treatments can be measured with repetitive testing.

Bursting with Energy presents eight secrets to achieve optimal mitochondrial activity. Of particular interest is Secret #8, which is restoring depleted hormones with bioidentical hormone therapies. Throughout the book Dr. Shallenberger explains how the energy production process is directed by hormones. Cortisol, growth hormone, insulin, progesterone, testosterone, and thyroid all contribute to this process. Hormones are intimately intertwined in the energy production in every part of the body.

For example, the adrenal glands function to control the blood sugar, glucose, which feeds energy production in the mitochondria. Stress depletes the adrenal glands. Adrenal hormones, such as cortisol and DHEA, assist in managing stress.  Patients may not seek professional help for fatigue until the functioning of the adrenal glands is exhausted. Dr. Shallenberger writes that a clue to early adrenal exhaustion is the presence of normal energy at rest but a decline in energy when challenged with exercise. Restoring depleted hormones can be an essential part of recovery.

Dr. Shallenberger has condensed decades of his clinical work and research into Bursting with Energy. A primer for the successful operation of your body, this book contains many secrets that anyone can start to apply. The best secret of all is that you can turn back the decline in energy and bring back life’s exuberance.

Book Review – Bursting With Energy by Frank Shallenberger 2018-04-07T11:11:17+00:00

Book Review – The Upside of Stress by Kelly McGonigal

Book Review – The Upside of Stress: Why Stress is Good for You and How to Get Good at It by Kelly McGonigal, PhD

Written by Carol Petersen, RPh, CNP – Women’s International Pharmacy

Stress is bad, right? It damages our body, causes depression, shortens our lives…the list goes on and on. We say things like, “All this stress is giving me an ulcer!” or, “This stress is killing me!” Your practitioner, if unable to pinpoint the source of your malady, may advise that you reduce your stress level. We have whole industries designed to decrease stress in our lives: yoga classes, meditation courses, massage therapy, breathing exercises, exercise, and life style coaching.

Dr. Kelly McGonigal urges us to rethink the idea that “stress is bad” in her book, The Upside of Stress: Why Stress is Good for You and How to Get Good at It. Dr. McGonigal is a health psychologist who teaches at Stanford’s School of Medicine Health Improvement Center and the Stanford Center for Compassion and Altruism.

A Little History
Dr. Hans Selye, an endocrinologist, found that introducing any sort of unpleasant experience produced a loss of muscle tone, ulcers, immune breakdown, and ultimately death in his lab rats. Having already seen human patients who experienced similar breakdowns in their health, he drew from his observations and his rat experiments to define stress as any demand made on the body. Further, he felt that just about anything that happened to someone in life (good or bad) was toxic.

Dr. McGonigal argues that Dr. Selye’s definition is much too broad. She believes there is a huge difference between the body’s response to near death experiences and electric shocks as the lab rats endured (she calls it The Hunger Games for rats!), and the everyday stresses of living life in the modern world that humans commonly experience.

Fight or Flight
The classic description of the body’s response to stress is “fight or flight.” The body reacts to a stressor by stopping all non-essential processes, like digestion and fertility, and releases a flood of energy and oxygen needed to flee a dangerous situation or to fight for survival. Although this process has served human beings and other animals well throughout millennia in their survival efforts, “fight or flight” may not be always appropriate in modern life. It isn’t very effective to run away from a disagreement with your boss or an argument with your spouse, and it isn’t possible to fight for survival against past due bills or an IRS audit. Dr. McGonigal points out our stress responses have adapted over time and aren’t limited to this one “fight or flight” response. We have developed many more coping strategies.

A More Finely Tuned Stress Response
Dr. McGonigal describes three types of stress responses in addition to “fight or flight,” which all serve to handle stress in such a way that may have a positive effect on the body:

  • Rise to the Challenge: This stress response allows us to focus our attention, heightens our senses, increases motivation and mobilizes our energy. This stress response is of benefit, for example, to an athlete who is about to compete.
  • Connect with Others: This stress response activates the need to protect our tribe and dampens fear and increases courage.
  • Learn and Grow: This stress response helps us integrate experiences and helps the brain learn.

The Main Stress Hormones
The hormones cortisol (also called hydrocortisone) and DHEA produced by the adrenal glands are considered the primary responders to stress. The outpouring of these hormones can affect the body positively rather than negatively. For example:

  • Research has shown that supplementing these stress hormones to enhance the stress response has been beneficial to those with post-traumatic stress disorder (PTSD) and panic attacks.
  • Psychiatrists have begun using these stress hormones before a therapy session and surgeons before surgery to improve outcomes.
  • Experiments designed to measure stress hormone responses find that those with the largest increase in DHEA are the most resilient under stress. DHEA can act as a neuro-steroid and actually help your brain grow stronger after stressful events.

Many More Hormones
While cortisol and DHEA are the main stress hormones, there are a number of other hormones involved in the body’s stress response.

  • Adrenaline (also called epinephrine) pours out of the adrenal glands with cortisol and DHEA, and serves to activate and focus our senses. The pupils of the eyes dilate to let in more light and hearing sharpens. The liver starts to dump fats and sugars into the blood stream to provide more energy for the brain and the muscles.
  • The release of endorphins, testosterone, and dopamine, along with adrenaline, actually provides a feeling of exhilaration that many find enjoyable. This “adrenaline rush” is the feeling thrill seekers are after when they skydive or ride roller-coasters.
  • Oxytocin is produced by the pituitary gland. Oxytocin increases our ability to bond with others and during times of stress, it allows our courage to dampen our fear. Interestingly, heart tissue contains many receptors for oxytocin which allow for regeneration and repair. Many believe that stress will give you a heart attack; however, the outpouring of oxytocin may actually strengthen your heart.

The Mindset
Early in her career, Dr. McGonigal , like many, believed that stress produces negative effects in the body. Then she came across a study that she just couldn’t reconcile with her belief system. This study documented that people who were exposed to stressors had different outcomes dependent upon their mindset about stress. If people believed stress was bad and produced unhealthy effects, it was so. If people believed stress was a part of life and a challenge to meet, they were healthier and even had enhanced life spans when compared to those with low levels of stress.

After this, Dr. McGonigal turned her career around. She no longer teaches fear of stress and stress management. She sums up her change in mindset in the introduction of her book: “The latest science shows that stress can make you smarter, stronger and more successful. It helps you learn and grow. It can even inspire courage and compassion.” She shares the tools to change one’s mindset in her book. Better yet, science shows that mindset is malleable for all of us.

Book Review – The Upside of Stress by Kelly McGonigal 2018-05-02T11:18:19+00:00

Book Review – The Statin Disaster by Dr. David Brownstein

Book Review – The Statin Disaster by David Brownstein, MD

Written by Carol Petersen, RPh, CNP – Women’s International Pharmacy

In this latest of Dr. David Brownstein’s books, he clearly states that statin medications fail to prevent or treat heart disease for nearly everyone who takes them. He also points out the shortcomings of the “cholesterol equals heart disease” theory. Dr. Brownstein is concerned because most busy practitioners do not take the time to fully understand the statistics used in drug studies well enough to critically examine the findings. This leaves practitioners to rely solely on the conclusions presented by the study investigators, who are often funded by pharmaceutical companies interested in bringing new drugs to market. Because of this, we are exposed to exaggerated claims of effectiveness when the actual facts may show otherwise.

What Are Statins?
Statins make up a class of drugs that lower the level of cholesterol in the blood by reducing the production of cholesterol by the liver. Statins reduce production of cholesterol in the liver by blocking an enzyme responsible for cholesterol production.

Statistics
Dr. Brownstein introduces us to a statistical concept known as the “number needed to treat.” This number can be calculated from data provided in studies, telling us how many people need to be treated with a medication for one person to benefit. The ideal number is one. When the number needed to treat is one, every person treated benefits from the treatment. Examples of therapies with a very low number needed to treat include patients with type 1 diabetes using insulin and patients with low thyroid function taking thyroid.

However, many of the drugs currently in use have a high number needed to treat. Numbers of 200 or more are seen regularly in studies using statins. In other words, 200 people need to be treated before one person will benefit. This might be acceptable if statins had no adverse effects and were completely without risk. Unfortunately, this is not the case. Adverse effects associated with statin use include muscle pain and damage, digestive problems, memory loss and confusion, increased blood sugar levels and Type 2 diabetes, and liver damage. These adverse effects may not happen to everyone, but if the number needed to treat for statins is 200, 199 people out of 200 using statins are taking the risk of experiencing an adverse effect while experiencing no benefit at all from the statin drug.

Based on Dr. Brownstein’s evaluation of the studies that have been done using statins, he states statins are effective for approximately 1% who take them. In other words, statins fail 99% who take them.

Is Cholesterol Good Or Bad?
The current perception about cholesterol is that there is “good” cholesterol and “bad” cholesterol. Cholesterol is neither good nor bad. We forget how important cholesterol is to our body’s daily functions. Cholesterol is an essential substance needed by every cell in the body. The human body uses cholesterol to make hormones, vitamins, and substances that help digest foods. If cholesterol levels are too high, our body is telling us something is not right. It would make sense to pay attention to our body’s signals and try to find the underlying cause of the elevated cholesterol levels rather than using medications to artificially lower levels. In addition, driving our cholesterol levels too low may create a whole new host of problems including problems with our immune systems and our resilience to infection.

How Do Hormones Play a Role?
Let’s zero in on hormones. Cholesterol is the source material for all sex hormones including estrogens, progesterone, testosterone, and adrenal hormones such as DHEA, and hydrocortisone. Our brains depend upon the hormones made from cholesterol as much as the rest of our body does. Progesterone and pregnenolone protect the nervous tissue throughout our body. Elevated cholesterol may simply be a signal the body is working hard to replenish these hormones in the event hormone levels are low. Cholesterol levels may also increase when thyroid hormone production is inadequate. Correcting sex hormone deficiencies and hypothyroidism for patients may bring their cholesterol levels down. Dr. Brownstein says he often sees patients in his practice where supplementing with sex or thyroid hormones brings cholesterol levels back into the normal range.

Dr. Brownstein says evidence-based medicine should be used and embraced. He feels the information is out there to expose statins as “one of the greatest failures in modern medicine.” According to Dr. Brownstein, our acceptance of such poor standards is mediocre medicine. We can and should determine what really makes a difference in our health. Reading his book will get us started.

  • Brownstein D. The Statin Disaster. West Bloomfield, MI: Medical Alternatives Press; 2015 www.drbrownstein.com
Book Review – The Statin Disaster by Dr. David Brownstein 2017-12-12T17:36:15+00:00

Book Review – An MD’s Life Saving Health Solutions by James A. Schaller

Book Review – An M.D.’s Life-Saving Health Solutions by James A. Schaller

Written by Carol Petersen, RPh, CNP – Women’s International Pharmacy

Although not apparent from the title of this book, An M.D.’s Life-Saving Health Solutions: A Gynecologist’s Advice, Dr. James Schaller shares some very interesting thoughts about hormones from his long clinical practice in obstetrics and gynecology. He writes in an engaging fashion, almost like you were sitting in his office and having a conversation with him.

He is very clear that progestins (which he calls castrating drugs) are not progesterone. He calls the large Women’s Health Initiative (WHI) study ill-conceived and and says it fails to answer the question that that they sought. The question asked by the study was “Can hormones delay the onset of chronic disease in women?” Because the study used only Premarin and Premarin with medroxyprogesterone (progestin), we only learned that the synthetic or non-human identical hormones do not delay the onset of chronic disease in women.

Dr. Schaller discusses the relationship between hormone balance and body fat at great length. He states ideally, a woman should have about 22% body fat. Less than 13% body fat and low estrogen at menopause is a real concern because there is not enough fat to allow for adequate estrogen storage. Consequently, very thin women have more sensitivity to swings in estrogen which occur throughout the cycle or in perimenopause. “Fat cells store, produce and release estrogen. The number of fat cells affects all hormonally-related effects,” Dr. Schaller claims.

Very thin women can experience stopped monthly periods because there is not enough estrogen available to build up the endometrium. Recall that cycling begins in a young woman who has at least 13% body fat. These women are also at higher risk for osteoporosis.

On the other hand, women who are overweight with more than 30% body fat, store plenty of estrogen in their fat cells. They have a life-long imbalance in progesterone needed to balance the estrogen they accumulate and store. Periods may also stop for obese women but they will likely experience abnormal bleeding.

It is important women understand normal ovarian function. Young girls usually experience pain during the first one to two days of their periods indicating that an ovulation has occurred. After a vaginal delivery this pain may stop. Pain can also occur at mid cycle or two weeks before bleeding begins. This pain can be stabbing or a dull ache and represents the pain of the follicle bursting through the ovary wall. He recommends avoiding strenuous activity when this happens. The ovaries can actually sway with rigorous exercise and prevent healing of the rupture in the ovarian wall.

Dr. Schaller’s book contains many more practical hints. He warns against using psychoactive drugs, medications that have an effect on mood, behavior, or thinking processes, for PMS when progesterone addresses the underlying issue and is less expensive too. He says statins are very dangerous. He notes that cholesterol-lowering drugs do not save lives but actually increase mortality and produce depression and memory problems.

Dr. Schaller is accepting of some doses of NSAIDS (non-steroidal anti-inflammatory drugs) for ovulation pain; however, he says using NSAIDs in excess can cause serious problems because of their potential for gastric ulceration. Drugs which are used for excess stomach acid actually prevent absorption of critical nutrients and bisphosphonate drugs used for osteoporosis interfere with normal bone metabolism.

It was a privilege to read this book and reap the benefits of the observations of a physician in practice for over 40 years. I am sad to see our medicine system turning into one which allows patients only a few minutes with a practitioner and uses treatment plans based on algorithms instead of treating people like individuals and tapping into the vast stores of knowledge and experience from physicians such as Dr. Schaller.

Book Review – An MD’s Life Saving Health Solutions by James A. Schaller 2018-01-22T10:56:17+00:00

Book Review – Adrenaline Dominance by Michael E. Platt, MD

Book Review – Adrenaline Dominance: A Revolutionary Approach to Wellness by Michael E. Platt, MD

Written by Carol Petersen, RPh, CNP – Women’s International Pharmacy

We know what a surge of adrenaline feels like. It is the hormone that gives us the strength for “fight or flight.” Our hearts beat harder, stronger, faster. Blood is diverted from less important things like digestion to our muscular tissue. Thought processes seem to happen at lightning speed. There are many stories of superhuman feats performed under extraordinary circumstances with surges of adrenaline.

Dr. Michael E. Platt has written his book Adrenaline Dominance because he feels that practitioners and their clients lack understanding of this very important hormone. He finds that knowing how adrenaline functions enables him to successfully guide his patients towards wellness.

Adrenaline is produced by an inner part of the adrenal glands. Dr. Platt explains that there are two reasons for adrenaline to be released: One reason is in response to stress as described above, and the second reason is to ensure that the brain has received enough sugar (glucose). The body uses adrenaline to help create more glucose from protein as well as stimulate the release of glucose stored in the liver. Consequently, as glucose releases, insulin releases. These two hormones are intimately involved with adrenaline.

Dr. Platt organized his book according to “The Good, the Bad and the Ugly,” the classic Clint Eastwood western, to illustrate that adrenaline has both desirable and undesirable effects. He believes that right-brained creative thinkers acquire those qualities from plenty of adrenaline ensuring lots of glucose to the brain. Superb athletes also get their edge from adrenaline. These are “good” mental and physical effects of generous amounts of adrenaline.

It starts to get “bad” when adrenaline output is too generous or our bodies don’t have the ability to moderate the high adrenaline. High adrenaline can be tied into depression, anxiety, irritable bowel syndrome, hypertension, diabetes, obesity, headaches, restless leg syndrome, addictions, and bedwetting. It gets “ugly” when syndromes such as fibromyalgia, interstitial cystitis, road rage, autism, or post-traumatic stress disorder appear.

Progesterone, which is also produced by our adrenal glands, is the natural modifier of excess adrenaline. Dr. Platt recommends progesterone in men and women, as well as children. Along with progesterone, Dr. Platt guides his patients with their food choices. Dr. Platt recognizes the relationship between glucose and insulin and claims the timing and types of foods ingested can make significant changes in the presentation of excess adrenaline.

It is not difficult to imagine the ramifications of adrenaline being out of balance since Dr. John Lee introduced us to the concept of “estrogen dominance.” Many practitioners surprisingly don’t recognize the significance of progesterone in moderating both the effects of estrogens and adrenaline. Thanks to Dr. Platt, we can raise our awareness on an ever enlarging picture about hormone balance. He reveals his evidence and thinking in great detail in his book, which is sure to expand every reader’s thinking about our bodies.

  • Platt ME. Adrenaline Dominance: A Revolutionary Approach to Wellness. Michael E. Platt, MD; 2014.
Book Review – Adrenaline Dominance by Michael E. Platt, MD 2018-04-03T16:34:47+00:00

Book Review – The Bulletproof Diet by Dave Asprey

Book Review – The Bulletproof Diet by Dave Asprey

Written by Carol Petersen, RPh, CNP – Women’s International Pharmacy

In “computerese,” to hack means to devise or modify a computer program, usually skillfully. Dave Asprey challenges us to use the concept of “biohacking” in his 2014 book, The Bulletproof Diet.

Dave Asprey is an early Silicon Valley computer engineer who made millions with Internet hacking. He describes hacking as needing to make complex systems work even when all the pieces of the puzzle are not available. In that respect, he came to understand that the human body is very much like a complex computer program, with some data that is missing or misunderstood. He speculated that it would be possible to use “biohacking” to solve his own health problems.

At the start of his quest, Dave Asprey writes, he was in miserable shape. He weighed 300 pounds and was unable to lose the extra weight, even though he followed various diets and a strenuous exercise program. Other health issues included chronic sinus infections, strep throat, foggy brain and difficulty maintaining focus. He was always tired and overwhelmed with the stress in his life.

Asprey came to look at his body as a complex system. He engaged in what he calls “biohacking,” or “the art of using technology to change the environment inside and outside of your body to take control and make it what you want.” His endpoints of success would be measures such as how he felt, how he performed, the success of his relationships with others, and overall happiness. Just as programmers look to find potential flaws, he took to “troubleshooting” his environment, evaluating what was working and what was not in a scientific manner.

In the end, he concluded that inflammation, toxins, hormones, neurotransmitters, gut bacteria and more play huge roles in the efforts to nourish our bodies and our brains. He asserts that the strongest variable in achieving top performance is—far and away—our diet.

In his “biohacking” journey, Asprey discovered that he had thyroid (Hashimoto’s), adrenal, testosterone and estrogen problems. Realizing that saturated fats and cholesterol are the building blocks for the sex and adrenal hormones, he deviated from the low-fat philosophy being promulgated and started eating butter from the milk of cows who had been raised eating grass. Magic happened as his focus increased, while his weight and inflammatory markers decreased.

Asprey discovered the importance of a molecule called vasoactive intestinal polypeptide (VIP) which, when depleted, disturbs our master glands (pituitary and hypothalamus). This leads to problems with insulin and glucose regulation, causing a craving for sweets. Paying attention to the proper functioning of VIP is one of the cornerstone ideas in The Bulletproof Diet.

Because our medical system prefers to use techniques such as double blind, crossover studies (which tend to limit the variables as much as possible), we are prevented from understanding our human functioning as a system. What usually evolves is something like the conventional treatment for hypothyroidism. Practitioners are taught to test for thyroid stimulating hormone (TSH). If the TSH gets too high because of the effort to stimulate more thyroid hormone production from the thyroid gland, a single thyroid hormone, l-thyroxine (T4), is prescribed. When the TSH level comes down because of the presence of T4, the treatment is considered a success. In truth, for vast numbers of people, the low thyroid symptoms are not relieved. Their practitioners are unable to shift from their linear thinking to a systems analysis, which requires “biohacking” until the other variables are revealed.

It has taken the efforts of an individual who is systems-minded (and who is trained to collect and evaluate data points in a scientific manner) to open our minds to a new approach to optimal health. Practitioners who have embraced using bioidentical hormones in a symphony of hormones have broken away from their linear thinking and learned to “biohack” for their patients. It’s revolutionary and exciting. Dave Asprey presents much more in his book, inviting us all to learn how to “biohack” our way to greater energy, focus and well-being.

  • Asprey D. The Bulletproof Diet: Lose up to a Pound a Day, Reclaim Energy and Focus, Upgrade Your Life. Emmaus, PA: Rodale Books; 2014.
Book Review – The Bulletproof Diet by Dave Asprey 2017-12-11T17:42:55+00:00

Book Review – Stop the Thyroid Madness II, ed. Janie A. Bowthorpe

Book Review – Stop the Thyroid Madness II edited by Janie A. Bowthorpe

Written by Carol Petersen, RPh, CNP – Women’s International Pharmacy

Janie Bowthorpe has become a force to be reckoned with. Her first book, Stop the Thyroid Madness, chronicles her return to health after decades of dealing with misdiagnoses and misguided treatments. She describes herself as suddenly becoming more alive after finding out about desiccated whole thyroid and changing from l-thyroxine (T4) treatment only. Her book can be an inspiration to anyone who struggles with reduced energy levels or never feels quite well. Bowthorpe is also the author of a blog, www.stopthethyroidmadness.com, in which she shares the huge amount of thyroid information she has discovered herself and gathered from others who she engaged through social media. Her first book is still the top selling book about thyroid issues on Amazon.

Bowthorpe has taken another direction with Stop the Thyroid Madness II (published by Laughing Grape Publishing, Dolores CO, 2014). In this volume, she serves as the editor of a collection of chapters written by practitioners who have recognized the complexity of thyroid issues. These practitioners have made large changes in their approach to recognizing thyroid dysfunction and assisting their patients to truly turn their health around.

The current standard for treating thyroid issues blessed by the society of endocrinologists is to only use one thyroid test, TSH or thyroid stimulating hormone, and then only to use one thyroid hormone, T4, to treat. After treatment, only the results of dropping serum TSH levels are used as a measure of success. Healthcare practitioners are taught that this standard prevails, while the fact that resolution of symptoms has not happened is dismissed.

Patients with thyroid disorders suffer from the fragmentation of medical care. Since thyroid hormone is needed to be active in every cell in the body, the symptoms of thyroid disease can occur anywhere. Patients can find themselves being shunted from endocrinologists to gastroenterologists, psychiatrists, and more. And when the approach mentioned above with T4 doesn’t pan out, it is assumed that the problems presented are not part of thyroid disease.

This book covers an astonishing amount of material. You will find yourself highlighting and earmarking the pages and rereading chapters to reinforce your understanding. Once you have reviewed this material, you will be armed to advocate for yourself in identifying and treating the underlying problems leading to your thyroid disorder.

To illustrate the scope of this book, here are some of the areas covered:

  • Gluten intolerance and sensitivity leading to thyroid autoimmune disorders
  • Defects in methylation identified with DNA testing
  • Toxic heavy metals that interfere with thyroid functioning and testing and detoxification modalities
  • Shortages of essential vitamins and minerals that are needed for thyroid production and conversions
  • Environmental pollutants that wreak havoc with thyroid and other hormones and how to identify and eliminate
  • The implications and circumstances that will cause the production of an inactive thyroid hormone called reverse T3 and how to return to production of the most active thyroid hormone T3
  • The pitfalls of laboratory testing and introduction of many more parameters to check thyroid activity
  • Foods that are helpful to include in your diet and those that must be eliminated for healthy thyroid function

A favorite chapter of mine is entitled “Why are Doctors Like That?” Reading this chapter can be enormously helpful when preparing to discuss the comprehensive information presented here with your practitioner. This material has not been taught in medical schools; only the practitioners who have challenged themselves to go further to help their patients have mastered it. You may also find practitioners who have studied and understand certain aspects of this topic, but who lack experience in the whole scope of problems affecting thyroid function. A good partner in your search for wellness should facilitate the unraveling of the mysteries underlying your health problems.

Although we live in a time when there are many more challenges to our health, we also have a wealth of information available to us. This enables us to take an active role in partnering with our health care practitioners to solve health care problems. Janie Bowthorpe is proof positive that your health can be regained. We can only admire the energy and determination that she displays by providing this depth of information to everyone.

Book Review – Stop the Thyroid Madness II, ed. Janie A. Bowthorpe 2017-12-14T12:25:11+00:00

Book Review – My Journey to a Better Bladder by Teri A. Larson

Book Review – My Journey to a Better Bladder by Teri A. Larson

Written by Carol Petersen, RPh, CNP – Women’s International Pharmacy

Given that our Connections newsletters are intended to help readers on a path to better health, we were ecstatic to learn that our newsletter titled A Quiet Epidemic of Bladder Troubles, along with an e-newsletter titled A Sense of Urgency, had been instrumental in Teri Larison’s research and subsequent publication of her e-book, My Journey to a Better Bladder.

Too often, when browsing the Health section in a bookstore or doing an internet search, you find coping strategies rather than real solutions. Teri’s book illustrates the power of the do-it-yourself options.

When Teri began to have bladder trouble, she engaged her OB/GYN and urologists, who treated her urgency or irritable bladder with antibiotics and drugs designed to dampen the nervous system irritability, but to no avail. Even Kegel exercises, which she thought would help the situation, were impossible for her to do.

Finally, the diagnosis from a cystoscopy indicated that Teri had a bladder prolapse, which prompted her to learn more about it. She was offered two choices: physical therapy, with little hope of healing; or surgery, which included adding meshes to hold the bladder in place. Although surgery was enthusiastically endorsed by her physician, an internet search alerted her to the possibility of outcomes that were less than ideal.

Teri used a scientific method to find relief from her irritable bladder. She thoroughly researched the implications of surgery and dismissed that as an option for herself. She carefully documented her research and her whole program, identifying the information that influenced her decisions. She then shared those results in her book.

Central to turning her condition around was having something in her vagina that would support her bladder. Products called vaginal pessaries are designed to do this, but Teri hit upon the idea of using a tampon. When she inserted one, she immediately felt that she was on the right track because the urgency diminished. Then she discovered that she could actually start doing Kegel exercises, which she found demonstrated on YouTube.

Teri also learned that diet affected her bladder, so she started making healthier food choices, avoiding the foods that were particularly irritating. One of the biggest hurdles to overcome was reversing the conditioning of her bladder to stop the sense of urgency, even when small amounts of urine had accumulated. She carefully examined her routines and started disconnecting the bathroom visits with certain activities, while also gradually increasing the time between bathroom visits. With all this in place, Teri reports that she successfully—on her own—conquered the misery of an irritable bladder. She devised charts and daily plans, which she used herself, and now provides for her readers.

After reading her book, I contacted Teri to share a few more tidbits of information. A family member who is an OB/GYN told me years ago that her mentor taught her about using a clean white handkerchief rolled tightly and inserted into the vagina to help with prolapse. Recently, I read (on the internet, of course) that pressing into the middle of the palm of the hand can relieve the sense of urgency to urinate for about 20 minutes. I used it myself with success while driving to an airport a few weeks ago.

I also suggested that Teri check into her testosterone levels. The bladder and urinary tract tissue are highly populated with testosterone receptors. Testosterone is the director in all protein metabolism and is thus a key player in all structural issues. Unfortunately, testosterone is a hormone that is often ignored in women’s health. In reality, normal testosterone levels exceed the levels of estrogens in women, so its importance should not be dismissed so lightly.

These days, our health system does not typically allow for adequate time to consult with the experts. However, there are many good resources available to help you fix the problem yourself. The internet offers opportunities never previously available to us, such as medical studies, original scientific research and, perhaps best of all, other people—like Teri—who are willing to share resources and their personal experiences.

For those who are eager to make a difference in their own bladder health, Teri offers a very comprehensive blueprint. She is also an inspiration to anyone who has a health problem to solve.

Book Review – My Journey to a Better Bladder by Teri A. Larson 2018-04-03T16:27:30+00:00