Medications and Thyroid Function

Written by Kathy Lynch, PharmD – Women’s International Pharmacy

 

Many medications can have a negative impact on thyroid function. For example, thyroid dysfunction often accompanies the debilitating brain and muscle side effects that have occurred in women who have received the hormone-suppressing drug Lupron or the HPV vaccine Gardasil.

These side effects are unusually similar to the inflammatory symptoms that accompany multiple sclerosis (MS). Years of animal research have demonstrated an improvement in MS symptoms after triiodothyronine (T3) administration. T3 seems to put the brakes on damage to the nerve sheath and actually promotes healing of the nerve.

People with inflammatory nerve conditions, who are also experiencing hypothyroid symptoms, may benefit from taking T3. Levothyroxine (T4) alone may not be enough, as studies have shown that critically ill patients with low thyroid function do not benefit from taking just T4.

  • Marrs C. Thyroid Dysfunction with Medication or Vaccine Induced Demyelinating Diseases. Hormones Matter. https://www.hormonesmatter.com/thyroid-medication-vaccine-induced-demyelination/: October 26, 2015.
  • Sutton I, et al. CNS demyelination and quadrivalent HPV vaccination. Mult Scler. 2009 Jan;15(1):116-119. Epub 2008 Sep 19.
  • D’Intino G, et al. Triiodothyronine administration ameliorates the demyelination/remyelination ratio in a non-human primate model of multiple sclerosis by correcting  tissue  hypothyroidism. J Neuroendocrinol. 2011 Sep;23(9):778-790.
  • Economidou F, et al. Thyroid function during critical illness. Hormones. 2011;10(2):117-124.
2018-04-04T15:39:34+00:00