Book Review:
Adrenaline Dominance 

- Dr. Michael Platt

Written by Carol Petersen, RPh, CNP - Women's International Pharmacy

We know what a surge of adrenaline feels like. It is the hormone that gives us the strength for "fight or flight". Our hearts beat harder, stronger, faster.   Blood is diverted from less important things like digestion to our muscular tissue. Thought processes seem to happen at lightning speed. There are many stories of superhuman feats performed under extraordinary circumstances with surges of adrenaline.


Dr. Michael E. Platt has written his book "Adrenaline Dominance" because he feels that practitioners and their clients lack understanding of this very important hormone   He finds that knowing how adrenaline functions enables him to successfully guide his patients towards wellness.


Adrenaline is produced by an inner part of the adrenal glands. 

Dr. Platt explains that there are TWO reasons for adrenaline to be released.   One reason is in response to stress as described above and the second reason is to ensure that the brain has received enough sugar (glucose).  The body uses adrenaline to help create more glucose from protein as well as stimulate the release of glucose stored in the liver.  Consequently, as glucose releases, insulin releases. These two hormones are intimately involved with adrenaline.


Sex Hormone Binding Globulin

Written by Carol Petersen, RPh, CNP - Women's International Pharmacy 

Hormone levels in the blood must be just right.


Steroid hormones include testosterone, estrogens, DHEA, and progesterone, among others. Steroid hormones are fat soluble, but our blood is mostly water.  Therefore, hormones and the blood do not mix very well.  The body's solution to this problem is sex hormone binding globulin (SHBG), a protein created by the liver which connects with the fat-loving hormones. The resulting complex becomes water soluble and can move freely in the blood stream.

SHBG carries these hormones throughout the body.  SHBG also acts as a reservoir for the hormones it carries and protects the hormones from hyperactive liver metabolism and kidney excretion.

SHBG combines with hormones to different degrees of affinity or attraction.  The most strongly bound hormone is dihydrotestosterone (DHT), the active form of testosterone, followed by testosterone itself.  SHBG also shows affinity, although considerably less, for estrogens, DHEA and even progesterone.  


Continue Reading

Testosterone and Heart Disease 

- The Continuing Saga

Written by Kathy Lynch, PharmD - Women's International Pharmacy


Evidence continues to mount that there is no scientific basis for the assumption that testosterone supplementation causes heart problems. The European Medicines Agency (EMA) recently reviewed the risk of serious cardiac problems in men using testosterone replacement.

Pharmacist Corner

EMA's Pharmacovigilance Risk Assessment Committee (PRAC) looked at major heart problems, particularly heart attacks. PRAC reviewed all recent negative studies plus data from positive studies and available safety data.  They concluded that there is "no consistent evidence of an increased risk of heart problems with testosterone medicines."  The PRAC also noted that there is evidence that low testosterone can increase the danger of heart problems.


This position has been adopted by the European Union.  The EMA does support the conservative position that only men who are low in testosterone should receive replacement. They recommend periodic monitoring of hemoglobin, hematocrit, liver function and cholesterol. They caution that men with severe heart, kidney or liver disease avoid testosterone altogether. Patients should talk to their doctor or pharmacist for further information.


  •  "No consistent evidence of an increased risk of heart problems with testosterone medicines."  Published by European Medicines Agency; Nov 21 2014.


Women's International Pharmacy 


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In This Issue
Book Review: Adrenaline Dominance
Sex Hormone Binding Globulin
Testosterone and Heart Disease

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