The evidence continues to mount that there is no scientific basis for the assumption that testosterone supplementation causes heart problems. The European Medicines Agency (EMA) recently reviewed the risk of serious cardiac problems in men using testosterone replacement therapy. The EMA’s Pharmacovigilance Risk Assessment Committee (PRAC) looked at major heart problems, particularly heart attacks.
EMA’s Findings Concerning Testosterone and Heart Disease
The committee reviewed all recent negative studies plus data from positive studies and available safety data. They concluded that there is “no consistent evidence of an increased risk of heart problems with testosterone medicines.” In addition, the PRAC noted that there is evidence that low testosterone may increase the danger of heart problems.
Practical Applications of These Findings
This position has been adopted by the European Union. The EMA supports the conservative position that only men who are low in testosterone should receive this hormone replacement therapy. They recommend periodic monitoring of:
- Liver function
They caution that men with severe heart, kidney, or liver disease should avoid testosterone altogether. Patients should talk to their doctor or pharmacist for further information.